Denture stomatitis is a chronic inflammatory lesion which is commonly associated with Candida albicans infection. It is frequently seen in complete denture patients and clinically presented as erythema and inflammation on the palatal mucosa. This review covers the different medical management of denture stomatitis. The first line of treatment is by topical antifungal agents, which are available as suspension, gels, lozenges, pastilles, etc. In patient where topical treatment was unsuccessful and in immunocompromised patient, systemic antifungal agents are prescribed. Recent studies have shown the effectiveness of natural products such as propolis, green tea extracts, and various essential oils in the treatment of denture stomatitis, to decrease colony count and reduce erythema of palatal mucosa.
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