Rifaximin is one of the common drug used in clinical practice in the management of traveler’s diarrhea, irritable bowel syndrome, and?hepatic encephalopathy. Hyponatremia is one of the rare side effect of this drug . We hereby present the case of a middle aged woman who was a known case of IBS: Diarrohea predominant who developed symptoms of hyponatremia after a short duration of rifaximin treatment, no other cause of hyponatremia was found on evaluation, so we suspect this as a rare side effect of rifaximin therapy.
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