ANALYTICAL STUDY OF HISTOPATHOLOGICAL CHANGES INDUCED BY OF ENDOSULFAN IN KIDNEY OF ALBINO RATS

摘要

An effective sub lethal dose (0.32 ppm/kg-1 bw) of endosulfan was injected to five week of albino rats and its exposure was studied in histopathology of kidney after15, 30 and 45 days of exposure. These histopathological changes in renal tissue of rats exposed to endosulfan by intradermal injection showed pronounced changes in the structure of renal corpuscle. The result of present study shows that exposure to endosulfan induced severe renal damages. the histopathological examination coupled with significant changes in kidney function The present findings suggested that endosulfan is a nephrotoxic chemical and that exposure to produces significant renal toxicity, in rats. Hence, stringent regulation of the use of endosulfan in our environments should be highly recommended to the various environmental protection agencies.