Permeability studies of anti hypertensive drug amlodipine besilate for transdermal delivery

摘要

Amlodipine besilate, an antihypertensive drug has a half–life of 35-50 hours and a bioavailability of 60-65 %. It undergoes extensive first pass metabolism. The Present study aims to evaluate suitability of transdermal drug delivery of amlodipine besilate. The partition coefficient in octanol / water system was studied, the effect of permeation enhancers SLS, β-cyclodextrin, DMSO, tween 20, sodium tauroglycolate and hyaluronidase on the drug release were studied using parchment paper. The flux and enhancement ratio calculations of amlodipine besilate were studied. The results indicated that the hyaluronidase enzyme show higher permeability and stead y state flux increased linearly with increasing donor concentration