Methylation dependent microRNA 1285-5p and sterol carrier proteins 2 in type 2 diabetes mellitus

摘要

Diabetes mellitus (DM) is one of the severe metabolic diseases found in all types of people’s lives in lower, middle and high income countries. It is suggested that the prevalence of diabetes is increasing in many countries and most of the cases are type 2?DM, clinical treatments are changing now to manage type 2?DM, however, up-to-date, there is no diagnostic, prognostic, and therapeutic target for type 2?DM. MicroRNAs (miRNAs) is one of a non-protein coding RNAs that have been regulating a wide range cellular processes and induce the development of many diseases. Most of the researchers concluded that miRNAs involvement is an important process in a broad range of signaling pathways such as cell proliferation, stem cell maintenance, migration, apoptosis and gene or protein expressions. Expressed sequence tags (ESTs) are the best source of coding and non-coding sequences for the identification of miRNAs. Although DNA methylation is an important mechanism for miRNAs up-regulation, this has not been highly explored in type 2?DM. The present study is useful to elucidate the molecular mechanism of MiR-1285-5p in type 2?DM and its role in disease progression and we discovered miR-1285 as a novel prognostic, diagnostic and therapeutic target for type 2?DM.