Correlation of the COMT Val158Met polymorphism with latitude and a hunter-gather lifestyle suggests culture–gene coevolution and selective pressure on cognition genes due to climate

摘要

Dual-inheritance theory posits that the genotype has an impact on the evolution of human behavior and that cultural traits can be constrained by genetic imperatives. A large body of studies provides evidence that the functional catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with executive function, working memory (WM), and intelligence. A survey of the population genetics database provides evidence that COMT gene frequencies vary across populations. The aim of the present study was to test the hypothesis that the COMT gene has an impact on cultural evolution, specifically on the adoption of an agricultural vs. a hunter-gatherer lifestyle. Statistically significant differences in COMT allele frequencies between hunter-gatherer and agricultural societies were found. Ethnic groups whose economy is based on farming have higher frequencies of the Met allele (symbol: A), whereas societies based on a hunter-gatherer economy have very low frequencies of the Met allele and a disproportionate predominance of the Val allele. Moreover, the frequency of the Met allele was positively correlated to the populations’ IQ ( r = 0.57). The FNBP1L gene (rs236330) is associated with childhood and adult intelligence and it varies in frequency across populations. Frequency of rs236330 was also significantly correlated with the populations’ IQ ( r = 0.81). COMT and FNBP1L had fairly similar geographical distributions ( r = 0.44) although the result did not reach statistical significance. The results suggest that the genotype of a population influences its cultural development in fairly specific and predictable ways. Met allele frequency was positively correlated with latitude ( r = 0.56), suggesting selective pressure due to climate.