Preparation of carboxymethyl-α-cyclodextrin polymer grafted onto nano TiO2 as a novel solid phase extraction sorbent based on a host–guest mechanism

摘要

Carboxymethyl-?±-cyclodextrin polymer grafted onto nano TiO2 (CM-?±-CD PGano TiO2) was fabricated and its feasibility for the determination of levodopa (L-DOPA) was investigated. The synthesized sorbent was characterized by Fourier transform infrared (FT-IR) spectroscopy, Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM). The adsorption mechanism is based on the hosta€“guest effect between L-DOPA and CM-?±-CD PG grafted on nano TiO2. The selectivity is due to the size of L-DOPA and also the hydrophobic interaction of CM-?±-CD polymer with this compound. The experimental conditions were optimized for the separation/determination of L-DOPA. Under the optimum conditions, the adsorption capacity of CM-?±-CD PGano TiO2 for L-DOPA and the preconcentration factor were 63.8 ??g ga?’1 and 20, respectively. The limit of detection (LOD), the relative standard deviation (RSD), and the linear range were 0.016 ??g mLa?’1, 2.3%, and 0.05a€“1.3 ??g mLa?’1, respectively.