A molecularly imprinted colloidal array (MICA) for the detection of clindamycin hydrochloride (CLI) was prepared by embedding a two-dimensional (2D) polystyrene crystalline colloidal array within a CLI-imprinted hydrogel. The MICA showed a significant response to CLI, in which the particle spacing of the MICA changed 41 nm within 10 min in response to 1 mM CLI, and the structural color of the MICA changed from blue, green, to yellow, and finally, to red. Furthermore, MICA was also used to detect a similar antibiotic, lincomycin, which had only induced a 10 nm change in the spacing. The MICA was reused more than 5 times. This low-cost and naked-eye sensing material provides a label-free way to detect CLI and other antibiotics.
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机译：通过将二维（2D）聚苯乙烯晶体胶体阵列嵌入CLI压印的水凝胶中，制备了用于检测盐酸克林霉素（CLI）的分子印迹胶体阵列（MICA）。 MICA显示出对CLI的显着响应，其中，响应1 mM CLI，MICA的粒子间距在10分钟内改变了41 nm，并且MICA的结构颜色从蓝色，绿色变为黄色，最后变为红。此外，MICA还用于检测类似的抗生素林可霉素，该抗生素仅引起间距变化10 nm。云母被重复使用了5次以上。这种低成本的裸眼感应材料提供了一种无标签的方式来检测CLI和其他抗生素。
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