A new label-free and turn-on fluorescence probe for hydrogen peroxide and glucose detection based on DNA–silver nanoclusters

摘要

We have developed a reliable, sensitive, label-free and turn-on sensor for H2O2 and glucose based on the cleavage of ssDNA by ??OH and the fluorescence enhancement effect when guanine-rich (G-rich) DNA sequences are in proximity to DNAa€“silver nanoclusters (DNAa€“Ag NCs). In addition, we have also proved that ??OH is indeed produced in the sensing system by adding antioxidants.