Hypocholesterolaemic action of Lactobacillus plantarum VJC38 in rats fed a cholesterol-enriched diet

摘要

This study was conducted to evaluate hypocholesterolaemic activity of probiotic strains Lactobacillus plantarum VJC38 and VJI21 in Wistar albino rats fed a cholesterol-enriched diet. The experimental animals were divided into five groups ( n ?=?6) viz., normal diet control group (NDC), hypercholesterolaemic diet (HD) control group (HDC), HD supplemented with 3?×?10_(8)?CFU/ml of L. plantarum VJC38 group (HD-C38), HD supplemented with 3?×?10_(8)?CFU/ml of L. plantarum VJI21 group (HD-I21), and HD supplemented with 3?×?10_(8)?CFU/ml of L. rhamnosus GG group (HD-GG) as positive control. Animals were administered bacterial culture by oral gavage once daily for 45?days. After trial, animals were sacrificed and blood samples were collected. Serum total cholesterol (T-CHO), triglyceride (TG), high-density lipoprotein (HDL) cholesterol, glucose, glutamyl pyruvate transaminase (GPT), and glutamyl oxaloacetate transaminase (GOT) levels were determined. Serum low-density lipoprotein (LDL) cholesterol levels were estimated using the Friedewald’s equation. Liver and fecal lipid contents and fecal cholic acids were measured. Serum T-CHO levels were significantly decreased by 15.6 and 17.4% in the HD-GG and HD-C38 groups, respectively, but not in the HD-I21 group compared with HDC group ( P ?