A Bacteriological Study of Bile in Gall Bladder Disease : A One Year Study in a Tertiary Care Centre in Assam, India

摘要

ABSTRACT Cholecystisis and cholelithiasis with its complication dominate the disease of the biliary tract.These diseases may cause severe infection and/or sepsis. In addition to surgical treatments, prompt administration of appropriate antibiotic is important to control the biliary tract infection. The purpose of this study is to illustrate the bacteriology in biliary tract disease and provide information for antibiotic choices. To isolate the bacterial flora from bile of gallbladder diseases and to determine the antimicrobial susceptibility pattern of different bacterial isolates. In this prospective study of one year study period from July 2006 to June 2007, a total of 50 bile samples was collected from patients undergoing cholecystectomy for gall bladder diseases in Surgical OT and isolated bacteria were identified and their antimicrobial sensitivity pattern studied by standard microbiological methods in a tertiary care hospital in Guwahati, Assam over a period of one year. Out of 50 bile samples, 24 (40%) showed positive bile cultures, the commonest aerobic organisms being E. coli and Klebsiella spp. Bacteroides fragilis was common among anaerobes. Gentamicin was the most effective drug among aerobes. Metronidazole, Chlorumphenicol & Imepenum being effective among anaerobes . Our bacteriological findings shows a changing trend in the microbial etiology and their antibiogram pattern which will help the clinicians  to formulate a proper and appropriate antibiotics used against pathogens, to reduce likelihood of complications like wound infections and gram negative septicemia. Keywords: Cholelithiasis, Cholecystectomy, Antibiogram