Formulation and Evaluation of Gastroretentive Floating Tablets of Cefixime trihydrate and Ofloxacin

摘要

ABSTRACT Cefixime Trihydrate is an antibiotic third generation cephalosporin. Cefixime Trihydrate is highly stable in the presence of β-lactamase enzymes. Cefixime Trihydrate is an effective treatment to stop the spread of several bacterial infections. Ofloxacin belongs to fluoroquinolones group of antimicrobials. Ofloxacin used to treat pneumonia and bronchitis caused by H.influenza. It is also used in treatment of skin infections caused by staphylococcus aureus and streptococcus pyrogens bacteria. It is mainly absorbed in stomach. Its PKa is 2.5 and 5.45 individually; therefore it remains unionized in stomach and maximum absorption take place from stomach only. Gastroretentive Floating tablets were formulated using HPMC K100M as polymer, Citric acid and Sodium Bicarbonate as Gas generating agent, Lactose as diluent and Magnesium stearate as Lubricant. The prepared tablets were evaluated for number of parameters like Weight Variation, Hardness, Friability, Drug Content, in vitro buoyancy studies, Swelling index, % Drug release Drug release kinetic, Anti bacterial study, Stability study. The best release for Gastroretentive floating tablet was shown by F19exhibited less floating lag time, highest floating time. Also Formulation F19 was given above 96% drug release after 12hr and above 97% drug content. In FTIR, drug to polymer interaction was not found and formulation F19 was found to be stable. Keywords: Cefixime Trihydrate, Ofloxacin, Gastro retentive floating tablets, Hydroxyl Propyl MethylCellulose.