CHADS2 score is predictive of left atrial thrombus on precardioversion transesophageal echocardiography in atrial fibrillation

摘要

Objective: The goals of this study were to determine: 1) if the CHADSsub2/sub score correlates with left atrial (LA) or left atrial appendage (LAA) thrombus on pre-cardioversion transesophageal echocardiography (TEE) in nonvalvular atrial fibrillation (NVAF); and 2) what, if any, components of the CHADSsub2/sub score are most important in predicting LA/LAA thrombus. Background: It is unknown if CHADSsub2/sub score, a marker of thromboembolic risk in NVAF, accurately predicts LA/LAA thrombus on pre-cardioversion TEE. Methods: We retrospectively studied patients undergoing precardioversion TEE for NVAF at a tertiary hospital. TEE reports were reviewed for presence of LA/LAA thrombus. Using medical records and an ICD-9 coding database, a CHADSsub2/sub score was derived, and the association between CHADSsub2/sub and thrombus was evaluated with Mantel-Haenszel Chi-Square. The relation between the singular components of CHADSsub2/sub and thrombus were analyzed using Pearson's Chi-Square. Results: In 643 consecutive patients undergoing pre-cardioversion TEE, LA/LAA thrombus was identified in 46 (7.2 %). A strong association was present between CHADSsub2/subscore and LA/LAA thrombus (p = 0.0005). No thrombi were identified in patients with CHADSsub2/sub = 0. Among 46 patients with thrombus, all (100%) had CHF. Of the singular components, CHF was the only factor independently associated with thrombus (p < 0.0001). Conclusions: In non-valvular atrial fibrillation, CHADSsub2/sub is strongly associated with LA thrombus on TEE. Our findings suggest pre-cardioversion TEE may be unnecessary if the CHADSsub2/sub score = 0. Of the components of the CHADSsub2/sub score, CHF was the only independently associated risk factor which correlated with LA/LAA thrombus.