ABSTRACT Carrier technology offers an intelligent approach for drug delivery by coupling the drug to a carrier particle such as microspheres, nanoparticles, liposomes etc. which modulates the release and absorption characteristics of the drug Microspheres constitute an important part of these particulate drug delivery system by virtue of their small size and efficient carrier characteristics. However, the success of these novel drug delivery system is limited due to their short residence time at the site of absorption. It would, therefore, be advantageous to have means for providing an intimate contact of the drug delivery system with the absorbing membranes. It can be achieved by coupling bioadhesion characteristics to microspheres and developing novel delivery systems referred to as “bioadhesive microspheres” This article contain the bioadhesive microspheres which have been developed for oral, buccal, nasal, ocular, rectal and vaginal routes for either systemic or local effects. This presents study include the spectrum of potential applications of bioadhesive microspheres in controlled drug delivery ranging from the small molecules, to peptides, and to the macromolecular drugs such as proteins, oligonucleotides and even DNA some Research Work on Bioadhesive Microspheres and Microcapsules. Various patent related to bioadhesive microsphere and Developments in the techniques for in vitro and in vivo evaluation of bioadhesive microspheres have also been discussed. From this study concluded that the bioadhesive microsphere can be efficiently used as controlled or targeted drug delivery. Keywords: Bioadhesive Microspheres; Controlled release drug delivery; Site Specific Bioadhesive Polymer, Application.
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