Pyruvate blocks blood-brain barrier disruption, lymphocyte infiltration and immune response in excitotoxic brain injury

Jae K Ryu; James G McLarnon

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Pyruvate blocks blood-brain barrier disruption, lymphocyte infiltration and immune response in excitotoxic brain injury

机译：丙酮酸阻断兴奋性脑损伤中的血脑屏障破坏，淋巴细胞浸润和免疫反应

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The effects of pyruvate, the end metabolite of glycolysis, on blood-brain barrier (BBB) impairment and immune reactivity were examined in the quinolinic acid (QA)-injected rat striatum. Extensive disruption of BBB was observed at 7 d post QA-injection as

机译：在注射喹啉酸（QA）的大鼠纹状体中检查了丙酮酸（糖酵解的最终代谢产物）对血脑屏障（BBB）损伤和免疫反应性的影响。 QA注射后7 d观察到BBB的广泛破坏，因为

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《American Journal of Neurodegenerative Disease》 |2016年第1期|共5页
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Jae K Ryu; James G McLarnon;
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中图分类神经病学与精神病学;
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6. Pyruvate blocks blood-brain barrier disruption lymphocyte infiltration and immune response in excitotoxic brain injury [O] . Jae K Ryu, James G McLarnon 2016

机译：丙酮酸阻断兴奋性中毒性脑损伤中的血脑屏障破坏淋巴细胞浸润和免疫反应
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机译：精氨酸加压素受体阻滞剂Conivaptan可减轻小鼠实验性卒中后脑水肿和血脑屏障的破坏。

Pyruvate blocks blood-brain barrier disruption, lymphocyte infiltration and immune response in excitotoxic brain injury

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