Aquagenic urticaria: Severe extra-cutaneous symptoms following cold water exposure

摘要

Aquagenic urticaria (AU) is a rare form of contact urticariamarked by pruritic wheals that rapidly develop after contactwith water, regardless of its temperature or pH.1e4 The conditionis characterized by follicular wheals, generally 1e3 mm in size,with an erythematous flare on sites exposed to water.1,2 AU usually subsides spontaneously within 30e60 min.2,3 Although mostcases have been sporadic, familial cases have been reported.5,6AU accompanied by extra-cutaneous symptoms has rarely beenreported.4,6 To our knowledge, there is only one published caseof AU with extra-cutaneous symptoms including shortness ofbreath, wheezing, dizziness and headache.6 Herein we reportthe first case of AU presenting with severe extra-cutaneoussymptoms, the severity of which correlated closely with watertemperature. The patient was successfully treated withloratadine.