Diagnosis and Surgical Treatment of Insulinoma in Sixteen Cases

摘要

Backgroud: Insulinoma is a rare tumor derived from B cells of pancreas islets, while recently, according to some researches, the incidence of insulinoma is increasing. It is believed that much more attention should be attached to the diagnosis and treatment of insulinoma. The goal of this retrospective study was to analyze the strategy for the surgical management of insulinomas. Methods: From May 2001 to October 2010, the medical records of 16 patients with insulinomas were included in our studied. We confirmed the diagnosis accoringd to a series of biochemical tests. Then all tumors were localized precisely by imaging techniques combined with intraoperative palpation. Except 4 patients who denied surgical treatment, all these patients was accepted follow-up after operation. Result: 11 patients with benign lesions underwent open surgical. 1 patient with malignant insulinomas underwent pancreaticoduodenectomy. The mean hospital stay was 17.0 ± 6.0 days after after the open procedures. 14 complications occurred in 7 patients following resection. On follow-up, 92% of the patients were free from symptoms, and surgical cure was achieved in 95% of the patients with benign insulinomas. Conclusion: The choice of the surgical strategy for the treatment of pancreatic insulinomas depends on size and location of the tumor and the risk of malignancy. The optimal surgical procedure is key to prevent postoperative complications.