Early Androgenetic Alopecia as a Predictor of Ischemic Heart Disease

摘要

Backgroundandaimofthestudy:Many reports linked Androgenetic Alopecia(AGA) and ischemicheart disease. We aimed in this study to predict the relation between early androgenic alopecia and ischemic heart disease. Subjectandmethod:This study was conducted on (100) male aged (20-30 years), suffering from early AGA > grade 2 (1) with no history of cardiac disease versus 100 apparently healthy age matched male as a control group with no history of cardiac disease. Measurement of blood Pressure, lipid profile, Resting high-quality 12 lead Electrocardiograms(ECG), Echo-cardiography were done. Results: No significant differences between patients and control group regarding age. The BMI and waist circumference of patient group were significantly higher compared with control. As regard family history: There were significant higher difference regarding positive family history of AGA and C.V.D in cases compared to control. Statistically significant higher level in systolic blood pressure (SBP), cholesterol and triglycerides (TG) in AGA group compared to control group, while no statistically significant differences in diastolic blood pressure(DBP), high and low density lipoprotein level ((HDL) (LDL)) in AGA group. ECG found abnormal finding in 4 AGA patient which was statistically significant. The cases with positive ECG finding undergo ECHO two (2) of them have normal ECHO and the other two (2) cases had mitral valve prolapse, which is considered normal finding in 2-3% of population. As regard family history of AGA; there were statistically significant higher levels of SBP and LDL in 74 cases compared with 26 cases with no family history of AGA. While, there were no statistically significant difference in DBP, TG, TC, HDL and ECG between both groups. As regard risk factors, only SBP and TG were significantly higher according to severity of alopecia but, there were no statistically significant difference regarding DBP, cholesterol, HDL and LDL, as well as ECG findings with increase severity. Smokers had significantly more severe alopecia, SBP, TG, LDL and ECG than non-smoker in patients group. There was significant increase in SBP, TG and HDL in smoker when compared with non-smoker in control group. ConclusionsandRecommendations: AGA could predict ischemic heart disease, all AGA patients should be screened for coronary artery disease.