Evaluation of Olive Leaf Extract Effects on Functional and Structural Changes of Liver Tissue Following Lipopolysaccharide Administration in Rats

摘要

Background: Olive leaves are considered as significant sources of bioactive phenolic compounds with superior antioxidant capacity, anti-inflammatory and radical scavenging. The aim of the present study was to evaluate the effects of olive leaf extract on liver tissue following LPS administration. Materials and Methods: 28 male Wistar rats were divided into control group, LPS, olive leaf extract 40mg/kg BW plus LPS and olive leaf extract 60mg/kg BW plus LPS groups. Control and LPS groups were treated with distilled water and olive leaf extract 40 & 60 mg/kg groups were administrated with olive leaf extract as oral for ten consecutive days. LPS and olive leaf extract groups (40 and 60 mg/kg ) received LPS ( Salmonella typhosa ,once 5mg/kg) in the 11supth/sup day as intraperitoneally. Results: LPS-induced hepatotoxicity was manifested by a significant elevation in serum levels of ALT and AST enzyme activities and triglyceride concentration in comparision with the control group (P0.001). Olive leaf extract supplementation, significantly decreased serum activity of ALT and AST enzymes and triglyceride concentration. Conclusion: Therefore, it seems olive leaf extract containing oleuropein, is able to prevent LPS-induced hepatotoxicity in rats.