Effect of Eight Weeks’ Resistance Training on Serum Levels of Irisin and Lipid Profile in Overweight Men’s with Nonalcoholic Fatty Liver Disease

摘要

Background: Exercise training have a positive effect on nonalcoholic fatty liver disease (NAFLD). However, effectiveness pathways of exercise training on NAFLD is unknown. Therefore, the present study was conducted to aim of investigate the effect of eight weeks’ resistance training on serum levels of irisin and lipid profile in overweight men’s with nonalcoholic fatty liver disease. Methods: This study subjects consist of 30 overweight men’s afflicted by NAFLD with average age 40.2 ± 2.5 and weight 75.5 ± 3.19, that randomly assigned in control (n=15) and resistance training (n=15) groups. Resistance training program performed for eight weeks and three sessions in week. Training load from 40 percent of 1RM in first week increased to 70 percent of 1RM in last week. 48 hours after last exercise session, blood samples collected and given variables measured and data were analyzed by means of SPSS-24 software and analyze covariance (ANCOVA) test. Results: Results indicated significant increase of irisin and HDL ( p =0.001) and significant decrease in LDL, TG and cholesterol ( p =0.001) in resistance training group compared to control group. Conclusions: It seems that, some of positive effect of resistance training in patient with NAFLD can be attributed to increase irisin levels and resistance training can play important role in modulate lipid profile in this patient.