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首页> 外文期刊>Alzheimer s Research & Therapy >Advantages and disadvantages of the use of the CSF Amyloid β (Aβ) 42/40 ratio in the diagnosis of Alzheimer’s Disease
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Advantages and disadvantages of the use of the CSF Amyloid β (Aβ) 42/40 ratio in the diagnosis of Alzheimer’s Disease

机译:在诊断阿尔茨海默氏病中使用CSF淀粉样蛋白β(Aβ)42/40的优缺点

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The cerebrospinal fluid (CSF) biochemical markers (biomarkers) Amyloidβ 42 (Aβ42), total Tau (T-tau) and Tau phosphorylated at threonine 181 (P-tau181) have proven diagnostic accuracy for mild cognitive impairment and dementia due to Alzheimer’s Disease (AD). In an effort to improve the accuracy of an AD diagnosis, it is important to be able to distinguish between AD and other types of dementia (non-AD). The concentration ratio of Aβ42 to Aβ40 (Aβ42/40 Ratio) has been suggested to be superior to the concentration of Aβ42 alone when identifying patients with AD. This article reviews the available evidence on the use of the CSF Aβ42/40 ratio in the diagnosis of AD. Based on the body of evidence presented herein, it is the conclusion of the current working group that the CSF Aβ42/40 ratio, rather than the absolute value of CSF Aβ42, should be used when analysing CSF AD biomarkers to improve the percentage of appropriately diagnosed patients.
机译:脑脊液(CSF)生化标志物(生物标志物)淀粉样β42(Aβ42),总Tau(T-tau)和在苏氨酸181磷酸化的Tau(P-tau181)已被证明可诊断由于阿尔茨海默氏病引起的轻度认知障碍和痴呆广告)。为了提高AD诊断的准确性,重要的是能够区分AD和其他类型的痴呆(非AD)。已建议在鉴定AD患者时,Aβ42与Aβ40的浓度比(Aβ42/ 40比例)优于单独的Aβ42浓度。本文回顾了有关使用CSFAβ42/ 40比值诊断AD的现有证据。根据本文提供的证据,当前工作组的结论是,在分析CSF AD生物标志物时应使用CSFAβ42/ 40比值,而不是CSFAβ42的绝对值,以提高适当诊断的百分比。耐心。

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