Synthesis of novel 2-quinolone derivatives

摘要

In this work, N-amino quinoline-2-one (2) has been synthesized by the reflux of coumarin (1) with hydrazine hydrate (99%) in ethanol for 12 h. The azomethines (3-6) were prepared from the corresponding aryl aldehydes and ketones. Tetrazine derivative (7) was prepared from the reaction of compound (2) with CS2 and hydrazine hydrate in the presence of potassium hydroxide. However, the reaction of compound (2) with thiol compounds afforded the derivatives (8-14).Finally, condensation of compound (11) with 4-hydroxy benzaldehyde brought about the derivative (15).The structures of the synthesized compounds were deduced by using some spectroscopic methods, FT-IR, UV-Visible and NMR.