Application of a nano-antimicrobial film to prevent ventilator-associated pneumonia: A pilot study

摘要

Ventilator-associated pneumonia (VAP) is one of the most common hospital-associated infections and has accounted for approximately 15% of all hospital-associated infections.?In 76% of the VAP cases, the same bacteria colonize the oral cavity and lungs.?Oral care interventions may play a role in the prevention of VAP, yet more than half of the hospitals do not have specific policies for the oral care of intubated patients. Oral cavity interlinks with respiratory tracts and digestive tracts. After surgery?has been performed?in these?areas, aerobic and anaerobic bacteria frequently induce operative wound infections in teeth,?gingiva?and supporting tissues of the teeth and tonsils. This study investigates the effects of a nanotechnology antimicrobial spray (JUC)?on?the?incidence of VAP. 320?patients diagnosed with VAP?were randomly divided into?treatment and?control groups.?After usingchlorhexidine?mouthrinse, the treatment group?used?a nanotechnology antimicrobial spray?to the nose and mouth.?The control group was given normal saline.?The incidence rate of VAP was significantly lower in the treatment (8.38%) than control group (54.24%) (p<0.01).?A?physical antimicrobial film?is?formed on the surface oforal and nasal?mucosa?after?using the?JUC?spray?which?effectively reduces?the microbial colonization in the?sprayed areas, thus reducing and delaying the incidence of VAP.