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首页> 外文期刊>ACS Omega >Quick Test for Determination of N-Bombs (Phenethylamine Derivatives, NBOMe) Using High-Performance Liquid Chromatography: A Comparison between Photodiode Array and Amperometric Detection
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Quick Test for Determination of N-Bombs (Phenethylamine Derivatives, NBOMe) Using High-Performance Liquid Chromatography: A Comparison between Photodiode Array and Amperometric Detection

机译:高效液相色谱法快速测定N炸弹(苯乙胺衍生物,NBOMe)的方法:光电二极管阵列和安培检测的比较

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The emergence of a new class of novel psychoactive substances, N-benzyl-substituted phenethylamine derivatives so-called “NBOMes” or “Smiles”, in the recreational drug market has forced the development of new sensitive analytical methodologies for their detection and quantitation. NBOMes’ hallucinogenic effects mimic those of the illegal psychedelic drug lysergic acid diethylamide (LSD) and are typically sold as LSD on blotter papers, resulting in a remarkable number of fatalities worldwide. In this article, four halide derivatives of NBOMe, namely, 2-(4-fluoro-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethan-1-amine, 2-(4-chloro-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethan-1-amine, 2-(4-bromo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethan-1-amine, and 2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethan-1-amine, were detected and quantified simultaneously using a high-performance liquid chromatographic method, and two detection systems were compared: photodiode array detection (detection system I) and amperometric detection via a commercially available impinging jet flow-cell system incorporating embedded graphite screen-printed macroelectrodes (detection system II). Under optimized experimental conditions, linear calibration plots were obtained in the concentration range of 10–300 and 20–300 μg mL–1, for detection systems I and II, respectively. Detection limit (limit of detection) values were between 4.6–6.7 and 9.7–18 μg mL–1, for detection systems I and II, respectively. Both detectors were employed for the analysis of the four NBOMe derivatives in the bulk form, in the presence of LSD and adulterants commonly found in street samples (e.g. paracetamol, caffeine, and benzocaine). Furthermore, the method was applied for the analysis of simulated blotter papers, and the obtained percentage recoveries were satisfactory, emphasizing its advantageous applicability for the routine analysis of NBOMes in forensic laboratories.
机译:在休闲药物市场上出现了新型的新型精神活性物质,即所谓的“ NBOMes”或“ Smiles”的N-苄基取代的苯乙胺衍生物,迫使人们开发了用于检测和定量的新的灵敏分析方法。 NBOMes的致幻作用类似于非法的迷幻药麦角酸二乙酰胺(LSD)的致幻作用,通常在吸墨纸上以LSD的形式出售,从而导致全球范围内大量死亡。在本文中,NBOMe的四种卤化物衍生物为2-(4-氟-2,5-二甲氧基苯基)-N-(2-甲氧基苄基)乙-1-胺,2-(4-氯-2,5-二甲氧基苯基)-N-(2-甲氧基苄基)乙烷-1-胺,2-(4-溴-2,5-二甲氧基苯基)-N-(2-甲氧基苄基)乙烷-1-胺和2-(4-碘使用高效液相色谱法同时检测和定量-2,5-二甲氧基苯基)-N-(2-甲氧基苄基)乙-1-胺,并比较了两种检测系统:光电二极管阵列检测(检测系统I)并通过市售的撞击式射流流通池系统进行电流检测,该系统结合了嵌入式石墨丝网印刷的大电极(检测系统II)。在优化的实验条件下,分别针对检测系统I和II在10–300和20–300μgmL–1的浓度范围内获得了线性校准图。对于检测系统I和II,检测限(检测限)值分别在4.6–6.7和9.7–18μgmL-1之间。两种检测器都用于分析LSD和在街道样品中常见的掺假物(例如对乙酰氨基酚,咖啡因和苯佐卡因)中存在的散装形式的四种NBOMe衍生物。此外,该方法还用于模拟吸墨纸的分析,所获得的回收率令人满意,强调了其在法医实验室常规分析中的有利应用。

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