Prototype of a computerized system to automatically supply the parameters needed to compute 95% confidence intervals for chemical (and other) measurements (in both biased and unbiased measurement form)

摘要

A prototype of a computerized system has been developed to automatically acquire,statistically test and supply the parameters needed (standard deviation and percent recovery--obtainedby running control samples) to compute 95% confidence intervals for chemical (and other)measurements contained in an organizations’s main database (or locally) and ultimately to unbias thosemeasurements and their confidence intervals. All sources of stochastic variation within the analyticalmethods are characterized, manipulated and corrected so as to provide parameters that are trulyrepresentative of the stochastic processes that occur in each individual analytical method as it is beingdone in a particular laboratory. This is done by running chemical, biological, microbiological orradiological control samples on specially designed computer spreadsheet forms over several analyticalruns that automatically test the data statistically as it is being accumulated. These forms and theircontrol samples are often suitable to be continued to be run for quality assurance purposes after theirrespective parameters have been obtained. The entire computerized system could be adapted andoperated from a particular internet website making it available to fee-paying subscribers all over theworld.