Not only diabetic polyneuropathy but also interstitial cells of Cajal dysfunction is a potential mechanism for diabetic cystopathy

摘要

Canda et al. [1] focused on the changes of interstitialcells of Cajal (ICCs) and neuronal tissue relatedto diabetes. The results of the current study showedthat the number of ICCs in the lamina propria anddetrusor muscle is decreased in diabetic patients.This may be an underlying pathomechanism of lowerurinary tract symptoms in patients with diabetes.Long lasting diabetes results in different urologicalcomplications in over 50% of cases. The most commoncomplications include diabetic bladder dysfunction(DBD), diabetic cystopathy, urinary tractinfections and sexual dysfunction. Diabetic cystopathy(DC) was first described by Moller in 1976. DCfeatures consist of an increased urinary bladder capacity,post voiding residual volumes and decreasedurinary bladder sensation and motor activity asa result of diabetic polyneuropathy. DBD is referredto a wide range of lower urinary tract symptoms thatencompass storage complaints (overactive bladder/detrusor overactivity) and voiding complaints (poorurinary bladder emptying or overflow urine incontinence),as well as other less clinically defined phenotypessuch as decreased sensation and increasedcapacity [2–5].