Pre‐Metastatic Niches: Macrophages‐Triggered Sequential Remodeling of Endothelium‐Interstitial Matrix to Form Pre‐Metastatic Niche in Microfluidic Tumor Microenvironment (Adv. Sci. 11/2019)

摘要

In article number 1900195 , Seok Chung, Seung Hyeok Seok, and co‐workers take the first step in providing direct evidence of sequential establishment of the pre‐metastatic niche triggered by monocytes and macrophages. The monocytes/macrophages‐mediated remodeling of endothelium‐interstitial matrix leads down a slippery slope for the circulating cancer cells to invade toward metastasis.