Cell Migration: Surface Curvature Differentially Regulates Stem Cell Migration and Differentiation via Altered Attachment Morphology and Nuclear Deformation (Adv. Sci. 2/2017)

摘要

Abstract Mesenchymal stem cells, harvested from the bone marrow, alter their behavior depending on the local curvature of the 3D-printed surfaces they are seeded upon, as described by Ansgar Petersen and co-workers in article number 1600347. While concave surfaces promote stem cell migration, convex surfaces enhance cell specification into bone cells, a process driven by curvature-dependent forces on the cell's nucleus.