A new inducible transgenic mouse model for C9orf72-associated GGGGCC repeat expansion supports a gain-of-function mechanism in C9orf72-associated ALS and FTD

Renate K Hukema; Fréderike W Riemslagh; Shamiram Melhem; Herma C van der Linde; Lies-Anne WFM Severijnen; Dieter Edbauer; Alex Maas; Nicolas Charlet-Berguerand; Rob Willemsen; John C van Swieten

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A new inducible transgenic mouse model for C9orf72-associated GGGGCC repeat expansion supports a gain-of-function mechanism in C9orf72-associated ALS and FTD

机译：C9orf72相关的GGGGCC重复扩增的新的诱导性转基因小鼠模型支持C9orf72相关的ALS和FTD的功能获得机制

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《Acta Neuropathologica Communications 》 |2014年第1期| 共页
作者
Renate K Hukema; Fréderike W Riemslagh; Shamiram Melhem; Herma C van der Linde; Lies-Anne WFM Severijnen; Dieter Edbauer; Alex Maas; Nicolas Charlet-Berguerand; Rob Willemsen; John C van Swieten;
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中图分类神经病学与精神病学 ;
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1. Retraction Note to: A new inducible transgenic mouse model for C9orf72-associated GGGGCC repeat expansion supports a gain-of-function mechanism in C9orf72-associated ALS and FTD [J] . Renate K. Hukema, Fréderike W. Riemslagh, Shamiram Melhem, Acta Neuropathologica Communications . 2016 ,第1期

机译：收回注意：与C9orf72相关的GGGGCC重复扩增的新诱导型转基因小鼠模型支持C9orf72相关的ALS和FTD的功能获得机制
2. Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD [J] . Lindsey D. Goodman, Mercedes Prudencio, Nicholas J. Kramer, Nature neuroscience . 2019 ,第6期

机译：毒性扩增的GGGGCC重复转录由C9ORF72相关FTD中的PAF1复合物介导
3. Repeat-associated non-AUG (RAN) translation mechanisms are running into focus for GGGGCC-repeat associated ALS/FTD [J] . Goodman Lindsey D., Bonini Nancy M. Progress in Neurobiology: An International Review Journal . 2019 ,第期

机译：重复关联的非八月（RAN）翻译机制始于GGGGCC重复相关的ALS / FTD焦点
4. MODELLING AND CRYSTALLOGRAPHY OF E. COLI STX2 TOXIN WITH BOUND LIGAND: DESIGN AND PRELIMINARY EVALUATION OF INHIBITORS IN A TRANSGENIC MOUSE MODEL OF DISEASE [C] . Jacobson J.M., Yin J., Kitov P. I. International Carbohydrate Symposium . 2013

机译：大肠杆菌STX2毒素与结合配体的建模与晶体学：疾病转基因小鼠模型中抑制剂的设计与初步评价
5. Factors That Mediate Expression of Unique Ggggcc Repeat Expansions in C9ORF72-Associated Als/Ftd [D] . Goodman, Lindsey D. 2019

机译：在C9ORF72相关的ALS / FTD中调解独特GGGGCC重复扩展的表达的因素
6. Retraction Note to: A new inducible transgenic mouse model for C9orf72-associated GGGGCC repeat expansion supports a gain-of-function mechanism in C9orf72-associated ALS and FTD [O] . Renate K. Hukema, Fréderike W. Riemslagh, Shamiram Melhem, 2016

机译：收回注意：与C9orf72相关的GGGGCC重复扩增的新的诱导型转基因小鼠模型支持C9orf72相关的ALS和FTD的功能获得机制
7. Retraction Note to: A new inducible transgenic mouse model for C9orf72-associated GGGGCC repeat expansion supports a gain-of-function mechanism in C9orf72-associated ALS and FTD [O] . Renate K. Hukema, Fréderike W. Riemslagh, Shamiram Melhem, 2016

机译：收回注意：与C9orf72相关的GGGGCC重复扩增的新诱导型转基因小鼠模型支持C9orf72相关的ALS和FTD的功能获得机制

A new inducible transgenic mouse model for C9orf72-associated GGGGCC repeat expansion supports a gain-of-function mechanism in C9orf72-associated ALS and FTD

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