Prevention of biofilm formation on artificial pacemakers: is it feasible?

摘要

Abstract Objective: To identify the antimicrobial agents used in the prevention of biofilm formation on artificial pacemakers. Methods: Literature review, in order to answer the following question: ?￠????What antimicrobial agents are applied to prevent biofilm formation on artificial pacemakers??￠???? The databases PubMed, Web of Science, Scopus, Science Direct, Cochrane, CINAHL, Embase, and LILACS were used in all languages and without time restriction. Results: The final sample consisted of five primary studies, mostly experimental laboratory ones. The investigations identified agents with promising potential for reduction or inhibition of biofilm formation on pacemakers. An association between physical-chemical agents and pharmacological antimicrobials was highlighted. Conclusion: Prevention of biofilm formation on pacemakers is feasible. Among the agents that stood out were rifampicin, AIGIS ???? , aqueous neobactrim formulation, and a plasma coating using a combination of trimethylsilane and oxygen for coating deposition.