REEVALUAREA PERFORMAN?ELOR DETERMIN?RII ANTICORPILOR ANTIOVARIENI ?N DIAGNOSTICUL INSUFICIEN?EI OVARIENE PREMATURE LA PACIENTELE CU BOAL? TIROIDIAN? AUTOIMUN?

摘要

Objective: To reassess the antiovarian antibodies test performance in the diagnosis of premature ovarian failure of the patients with autoimmune thyroid disease. Material and method: The study involved 70 patients with autoimmune thyroid disease, from which ten cases (10/70, 14.4%) were associated with premature ovarian failure and were found to have serum antiovarian antibodies, using as reagent a mixture of ovarian proteins; the values greater than 10 IU/mL were considered positive. Results: Antiovarian antibodies were positive in one case (1,4%, 1/70) and was not a case of premature ovarian failure; in the same case antinuclear antibodies were positive. Conclusions: Determination of the circulating antiovarian antibodies as a possible predictive factor for premature ovarian failure is not really sustained, especially because it doesn’t exist a recognized specific marker of the ovarian autoimmunity, and the study results are statistically insignificant.