Antihypertensive activities of the plasteins derived from casein hydrolysates in spontaneously hypertensive rats

摘要

ABSTRACT Two casein plasteins were prepared from the Neutrase-catalyzed plastein reaction of casein hydrolysates in the presence of proline and phenylalanine, respectively, and assessed for their antihypertensive activities at 300????mg/kg body using rat model. After being oral administered, the two plasteins at initial time of 2?￠????6????h resulted in the rats decreased systolic and diastolic blood pressures of 10?￠????23 and 8?￠????19????mmHg, respectively; however, the measured antihypertensive activities showed decreasing trends as oral administrating time prolonged. The two plasteins also decreased serum levels of angiotensin II, angiotensin I converting enzyme, and aldosterone, but had unclear effect on serum angiotensinogen level. The two plasteins showed same antihypertensive activities without statistical difference ( p???? >????0.05), and were more efficient than casein hydrolysates but less effective than captopril ( p????