Objective To study the antihypertensive effects of s corn protein and its hydrolysates on spontaneouslyrnhypertensive rats (SHR). Methods Sixty 6-8 week-old male SHR were randomly divided into 5 groups: group A (cornrnprotein) , group B (corn protein's hydrolysate prepared with pepsin) , group C ( corn protein's hydrolysate prepared withrntrypsin) , group D (corn protein's hydrolysate prepared with complex enzyme) and group E( saline). Each group werernorally adiministered at dose of 1 g/kg body weight. Subsequently, systolic blood pressure of SHR was measured at a fixedrntime interval (0, 1 , 2, 4, 6 and 8 h) post-adiministration. Results Results showed that all hydrolysates had significantrninhibition on blood pressure of SHR and compound enzyme hydrolysate had the strongest effect on antihypertension during 0rn-6 h, with SBP decreased significantly which compared with group A, B, C and E (P < 0. 01). Conclusion Arnsignificant decrease in systolic blood pressure of SHR was observed in group, B, C and D.%目的 探讨玉米蛋白及其水解产物对自发性高血压大鼠(SHR)血压的影响.方法 6～8周龄雄性SHR大鼠60只随机分为A组(玉米蛋白组)、B组(胃蛋白酶水解产物组)、C组(胰蛋白酶水解产物组)、D组(复合酶水解产物组)和E组(生理盐水对照组),每组12只动物,均以1 g/kg体重剂量灌胃,测定灌胃0、1、2、4、6、8h后SHR血压值.结果 胃蛋白酶水解产物、胰蛋白酶水解产物和复合酶水解产物在0～6h内对SHR的血压升高具有明显抑制作用,其中0～2h内降血压效果明显；各组水解产物中,以复合酶水解产物在0～6h内降压效果最佳,SBP与生理盐水对照组、胃蛋白酶水解产物组和胰蛋白酶水解产物组相比具有极显著差异(P＜0.01).结论 玉米蛋白胃蛋白酶、胰蛋白酶和复合酶水解产物能有效地降低SHR大鼠的血压,为其在保健食品领域及医药方面的开发应用提供了参考.
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