Распространенность полиморфизма -262С/Т гена каталазы (rs1001179) у русских и бурят Восточной Сибири с эссенциальной артериальной гипертензией

摘要

Genetic variations that predispose individuals to complex disorders, such as essential hypertension, may be found in gene coding regions, intronic regions or in gene promoter region. Catalase is an endogenous antioxidant enzyme that neutralizes hydrogen peroxide and is induced by oxidative challenge. In this report we assessed the association between polymorphism -262С/Т in the promoter region of the CAT genes (rs1001179) and essential hypertension in Russian and Buryat populations of Eastern Siberia. In Russian population the frequencies of genotypes were: CC - 58,82 %; CT - 32,35 %; TT - 8,83 %, alleles C - 75 % and T - 25 %. In Buryat population the frequencies of genotypes were: CC - 90 %; CT - 7,5 %; TT - 2,5 %, alleles C - 93,75 % and T - 6,25 %. Statistically significant differences between the frequencies in control and examined groups (х 2 = 14,250; р = 0,000) were found in the group of Buryat population.