Ruthenium Based Photosensitizer Exerts Immunostimulatory and Possible Adjuvant Role on the Mammalian Macrophages In vitro

摘要

Immune system cells play a crucial role against different types and scales of danger in our body. Macrophages, one of the major innate immune system cells, can recognize the danger and produce different kinds of inflammatory signals as well as present the antigen to the other immune system cells to produce a proper immune response. The new era of medicine is focusing on the regulation of the immune system cells in order to eliminate the chronic inflammation induced by infections or to eliminate the tumors with the patients’ own immune system, that would bring out a more sustainable and permanent cure. In order to screen new candidates in the light of this approach, we tested the immunomodulatory and immunostimulatory capacities of ruthenium polypyridyl based complex K28 that is used in solar cells. Our results suggest that K28 was able to stimulate the pro-inflammatory activity of the mammalian macrophages based on the TNFa and IL1b production levels. K28 has potential to be used as an adjuvant based on our in vitro results. Immune system cells play a crucial role against different types and scales of danger in our body. Macrophages, one of the major innate immune system cells, can recognize the danger and produce different kinds of inflammatory signals as well as present the antigen to the other immune system cells to produce a proper immune response. The new era of medicine is focusing on the regulation of the immune system cells in order to eliminate the chronic inflammation induced by infections or to eliminate the tumors with the patients’ own immune system, that would bring out a more sustainable and permanent cure.. In order to screen new candidates in the light of this approach, we tested the immunomodulatory and immunostimulatory capacities of ruthenium polypyridyl based complex K28 that is used in solar cells. Our results suggest that K28 was able to stimulate the pro-inflammatory activity of the mammalian macrophages based on the TNFa and IL1b production levels. K28 has potential to be used as an adjuvant based on our in vitro results.