The Association Between CYP 2C19 Genotype and of In‐stent Restenosis Among Patients with Vertebral Artery Stent Treatment

摘要

Summary Aims Preventing stroke through endovascular treatment with vertebral artery stent remains a great challenge due to the occurrence of an in‐stent restenosis. Materials & Methods In this study, a retrospective analysis was conducted in 90 patients who had been treated with VAS between 2004 and 2011 in N anjing D rum T ower H ospital. Patients were followed up at 3 months, 6 months,and 1 year after VAS treatment and annually thereafter. For each time point, neurological function tests, vessel ultrasound and computer tomography angiography were performed to preliminarily screen the vessel stenosis. Digital subtraction angiography was used to verify the narrow sign on CTA or ultrasound. Clinical features of each patient including clopido‐grel metabolization genes ( CYP 2 C 19, CYP 3A4, and P 2 Y 12) were recorded with purpose to investigate the possible risk factors for the development of ISR . Results Single factor analysis dem‐onstrated that hyperlipidemia ( P Conclusion The study leads to the conclusion that hyperlipidemia and CYP 2 C 19 impotency are possible risk factors for the development of ISR in VAS ‐treated patients with ischemic. Moreover, VAS ‐treated patients with CYP 2 C 19 impotency were susceptible to recurrent stroke during our 54‐month follow‐up.