The Role of the Lactadherin in Promoting Intestinal DCs Development In Vivo and Vitro

摘要

Lactadherin, as one of the immune components in the breast milk, might play a role in the intestinal immune system of newborn. Therefore, we investigated the effect of lactadherin-feeding in early time on the development of intestinal immune system compared with naturally rearing and artificially rearing (non-lactadherin). In the present study, we observed that the Peyer's Patches (PP) from the pups of artificially reared group with lactadherin added were characterized by an excess of OX62~(+)CD4~(+)SIRP~(+)DC cells and a higher expression of CD3~(+)CD4~(+)CD25~(+)T cells. Additionally, this study also demonstrated that IL-10 production was dramatically increased when lactadherin was present in culture medium compared with lactadherin-absent culture. These results suggested that lactadherin could adjust intestinal DCs activity, induce CD3~(+)CD4~(+)CD25~(+)T cell differentiation, and enhance IL-10 production.