Antimicrobial Therapies for Pulmonary Klebsiella pneumoniae Infection in B6D2F1/J Mice Immunocompromised by Use of Sublethal Irradiation

摘要

Klebsiellapneumoniaeisacommoncauseofnosocomiallyacquiredpneumoniainimmunocompromisedpatients.Previously,weestablishedapneumoniamodelusingKlebsiellapneumoniaeinB6D2Fsubxmlns="http://pub2web.metastore.ingenta.coms/"1/sub/Jmicesublethallyirradiatedwith7-Gysupxmlns="http://pub2web.metastore.ingenta.coms/"60/supCo#59138;-radiationandinoculatedintratracheally.Inthestudyreportedhere,weinvestigatedsurvivalofmicefollowing10daysofantimicrobialtherapywithceftriaxone,gentamicin,gatifloxacin,andaceftriaxone-gentamicincombinationgivenoncedaily.Survivalwassignificantlyprolongedinresponsetoalltherapies.However,survivalofmicewas95%whentreatedwiththeceftriaxone-gentamicincombinationfollowedbyceftriaxonealone(75%),andgatifloxacin(80%),whereassurvivalforcontrolswas0%.Inaddition,resistancetoanyofthetreatmentsdidnotdevelopduringthestudy.WeconcludethatanimmunocompromisedstatusdoesnotaltertheInfectiousDiseaseSocietyofAmerica'sprimaryrecommendationfortreatingcommunity-acquiredK.pneumoniaepneumoniausingathird-generationcephalosporin,withorwithoutanaminoglycoside.