Validation of Nitroreductase, a Prodrug-activating Enzyme, Mediated Cell Death in Embryonic Zebrafish (Danio rerio)

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Validation of Nitroreductase, a Prodrug-activating Enzyme, Mediated Cell Death in Embryonic Zebrafish (Danio rerio)

机译：验证硝基还原酶（一种前药激活酶）介导的胚胎斑马鱼（Danio rerio）细胞死亡

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EscherichiacoligenenfsBencodesanitroreductase(NTR)enzymethatconvertsprodrugslikemetronidazole(Met)andCB1954tocytotoxicmetabolites.MycoworkersandIhavevalidatedthisprodrug-enzymesysteminzebrafish(Daniorerio)byubiquitouslyexpressingNTR#8211;EGFPfusionproteinandexposingtheseembyostoCB1954andMet.Theseembryosshowedextensivegrosspathologicchangesanddeathby24hofincubationintheprodrugs.Theyalsoexhibitedwidespreadandmarkedapoptoticchangesby8hofincubationinMet.NeithertheprodrugsthemselvesnortheNTR#8211;EGFPfusionproteinweretoxictothedevelopingzebrafishembryos.ThustheNTR#8211;CB1954andNTR#8211;Metsystemscanbeusedtoablateawidevarietyofcellsandtissuesinzebrafishembryos.

机译：EscherichiacoligenenfsBencodesanitroreductase（NTR）enzymethatconvertsprodrugslikemetronidazole（Met）的andCB1954tocytotoxicmetabolites.MycoworkersandIhavevalidatedthisprodrug-enzymesysteminzebrafish（Daniorerio）byubiquitouslyexpressingNTR＃8211; EGFPfusionproteinandexposingtheseembyostoCB1954andMet.Theseembryosshowedextensivegrosspathologicchangesanddeathby24hofincubationintheprodrugs.Theyalsoexhibitedwidespreadandmarkedapoptoticchangesby8hofincubationinMet.NeithertheprodrugsthemselvesnortheNTR＃8211; EGFPfusionproteinweretoxictothedevelopingzebrafishembryos.ThustheNTR＃8211; CB1954andNTR＃8211; Metsystemscanbeusedtoablateawidevarietyofcellsandtissuesinzebrafishembryos。

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《Comparative Medicine》 |2007年第3期|共页
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Validation of nitroreductase, a prodrug-activating enzyme, mediated cell death in embryonic zebrafish (Danio rerio) [J] . Pisharath H Comparative Medicine . 2007,第3期

机译：验证硝基还原酶（一种前药激活酶）介导的胚胎斑马鱼细胞死亡（Danio rerio）
2. Effects of two strobilurins (azoxystrobin and picoxystrobin) on embryonic development and enzyme activities in juveniles and adult fish livers of zebrafish (Danio rerio) [J] . Jia Wei, Mao Liangang, Zhang Lan, Chemosphere . 2018,第SEPa期

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3. Toxicomorphomics and toxicokinetics of quinalphos on embryonic development of zebrafish (Danio rerio) and its binding affinity towards hatching enzyme, ZHE1 [J] . Yashwanth Bomma, Pamanji Rajesh, Rao J. Venkateswara Aquatic Toxicology . 2016,第Null期

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Validation of Nitroreductase, a Prodrug-activating Enzyme, Mediated Cell Death in Embryonic Zebrafish (Danio rerio)

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