The Genetic Immunodeficiency Disease, Leukocyte Adhesion Deficiency, in Humans, Dogs, Cattle, and Mice

摘要

Thisreviewhighlightsthegenotype-phenotyperelationshipofthegeneticimmunodeficiencydiseaseleukocyteadhesiondeficiency(LAD)inhumans,dogs,cattle,andmice,andprovidesassessmentoftheopportunitiesthateachanimalspeciesprovidesintheunderstandingofleukocytebiologyandindevelopingnewtherapeuticapproachestoLADinhumans.Thiscomparisonisimportantsinceanimalmodelsofgeneticdiseasesinhumansprovidetheopportunitytotestnewtherapeuticapproachesinanappropriate,disease-specificmodel.Thesuccessofthisapproachisdependentontherelationshipofthephenotypeintheanimaltothephenotypeofthediseaseinhumans.