Prognostic value of tumor size in stage II and III colorectal cancer in Tunisian population

摘要

Aim: We aimed to identify a cutoff value of tumor size (TuS) correlated to prognosis of stage II and III colorectal cancer and to evaluate the prognostic significance. Patients & methods: We retrospectively analyzed 257?patients treated for stage II–III colorectal cancer between 2003 and 2014. We used receiver-operating characteristic to evaluate TuS performance accuracy to predict survival. We identified a cutoff value. We used the Kaplan–Meier method and Cox regression analysis to study survival and prognostic factors. Results: Area under the receiver-operating characteristic curve of TuS was 0.62?±?0.048. A size of 4?cm was identified as a predictor of survival with a sensitivity of 88.2% and a specificity of 59.2%. We observed 98?patients with TuS ≤4?cm and 159?patients with TuS greater than 4?cm. Patients with TuS greater than?4?cm were more likely to have a cancer located in the colon (81.1 vs 70.4%, p?=?0.002) and commonly pT4 (44?vs 22.4%, p?=?0.0001). There was no difference in terms of gender, i...