Dynamic changes of QTc interval and prognostic significance in takotsubo (stress) cardiomyopathy

摘要

Abstract BackgroundProlonged QT corrected (QTc) intervals are associated with adverse cardiovascular outcomes both in healthy and high-risk populations. Our objective was to evaluate the QTc intervals during a takotsubo cardiomyopathy (TTC) episodes and their potential prognostic role. HypothesisDynamic changes of QTc interval during hospitalization for TTC could be associated with outcome at follow-up. MethodsFifty-two consecutive patients hospitalized for TTC were enrolled. Twelve-lead electrocardiogram (ECG) was performed within 3?h after admission and repeated after 3, 5, and 7?days. Patients were classified in 2 groups: group 1 presented the maximal QTc interval length at admission and group 2 developed maximal QTc interval length after admission. ResultsMean admission QTc interval was 493?±?71?ms and mean QTc peak interval was 550?±?76?ms ( P ConclusionsProlonged QTc intervals at admission during a TTC episode could be associated with a higher risk of cardiovascular rehospitalization at follow-up. Dynamic increase of QTc intervals after admission are characterized by a trend toward a better prognosis.