c-Myc (Myc) and cancer literatures

摘要

c-Myc (Myc) is a regulator gene coding for a transcription factor. The c-Myc protein is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The mutated c-Myc is found in many cancers, which makes it be persistently expressed. This causes to the unregulated expression of many genes, some of which are involved in cell proliferation and results in the formation of cancer. Malfunctions in c-Myc have been found in carcinoma of the cervix, colon, breast, lung and stomach, etc. c-Myc is considered as a promising target for anti-cancer drugs