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A DASH dietary pattern and the risk of colorectal cancer in Canadian adults

机译:DASH饮食模式和加拿大成年人大肠癌的风险

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Introduction: Colorectal cancer ( CRC ) is a high incidence cancer affecting many Canadian adults each year. Diet is important in the etiology of CRC with many dietary components identified as potential risk factors. The Dietary Approaches to Stop Hypertension ( DASH ) diet is a well-established pattern to characterize overall eating. The purpose of this study was to characterize a DASH pattern within the Canadian context and to assess its relationship to the risk of CRC in Canadian adults. Methods: Unconditional multiple logistic regression with control for confounding variables was performed using data from the National Enhanced Cancer Surveillance Study. Dietary intake was captured for this case-control study through a food frequency questionnaire ( FFQ ) and categorized into a DASH score ranging from 0 to 10 representing a poor to a strong DASH pattern respectively. Results: Consuming a strong DASH pattern of eating (score ≥ 8) was not common in the 3161 cases and 3097 controls. Overall, only 10.8 % of men and 13.6 % of women had a strong DASH pattern. Multivariate analysis demonstrated a trend for decreasing risk of CRC in men with increasing DASH scores (p value for trend = .007). Men with a strong DASH score had a 33% reduction in risk of CRC compared to those with a low DASH score. There were no significant trends for women for CRC or for colon or rectal cancers separately. Conclusion: Our findings are similar to other researchers suggesting a benefit with a strong DASH pattern associated with a decreased risk of CRC , especially in men. Research should further investigate our gender-based differences.
机译:简介:结肠直肠癌(CRC)是一种每年都会感染许多加拿大成年人的高发癌症。饮食在CRC的病因中很重要,许多饮食成分被确定为潜在的危险因素。停止高血压的饮食方法(DASH)饮食是公认的总体饮食特征。这项研究的目的是在加拿大背景下表征DASH模式,并评估其与加拿大成年人CRC风险的关系。方法:使用来自美国国家癌症监测研究的数据,对混杂变量进行控制,进行了无条件的多逻辑回归。该病例对照研究通过食物频率问卷(FFQ)捕获了膳食摄入量,并将其DASH评分分为0到10,分别代表了DASH模式从差到强的DASH模式。结果:在3161例病例和3097例对照中,饮食中DASH的强度较高(得分≥8)并不常见。总体而言,只有10.8%的男性和13.6%的女性具有强烈的DASH模式。多变量分析表明,随着DASH评分的升高,男性患CRC的风险呈下降趋势(趋势的p值= .007)。 DASH得分高的男性与DASH得分低的男性相比,CRC风险降低33%。对于女性,CRC,结肠癌或直肠癌没有明显的趋势。结论:我们的发现与其他研究人员相似,表明强DASH模式有益于降低CRC风险,特别是在男性中。研究应进一步调查我们基于性别的差异。

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