Relationship between serum high-sensitivity C-reactive protein and modified TOAST classification as well as OCSP subtypes in patients with acute ischemic stroke

摘要

This paper aims to investigate the relationship between serum high-sensitivity C-reactive protein (hs-CRP) level and modified TOAST classification as well as OCSP subtypes in patients with acute ischemic stroke. Serum hs-CRP was measured in 240 patients with acute ischemic stroke and 120 normal controls. All patients were classified according to modified TOAST classification and OCSP criteria. Serum hs-CRP levels in acute ischemic stroke group were significantly higher than those in normal control group [(13.68 ± 6.92) mg/L vs (3.98 ± 0.76) mg/L; t = 6.922, P = 0.002]. Among modified TOAST subtypes, the highest serum hs-CRP level was in cardioembolism (CE) group [(16.82 ± 6.16) mg/L], followed by arterothrombosis (AT) group [(15.17 ± 5.68) mg/L], stroke of undetermined etiology (SUD) group [(10.06 ± 3.89) mg/L] and small artery disease (SAD) group [(9.86 ± 3.75) mg/L, P = 0.027]. Among OCSP subtypes, the highest serum hs-CRP level was in total anterior circulation infarct (TACI) group [(17.02 ± 6.98) mg/L], followed by posterior circulation infarct (POCI) group [(15.91 ± 7.12) mg/L], partial anterior circulation infarct (PACI) group [(12.83 ± 4.95) mg/L] and lacunar infarct (LACI) group [(10.61 ± 5.73) mg/L, P = 0.005]. Serum hs-CRP levels are various in different modified TOAST and OCSP subtypes, which may reflect etiological and pathophysiological diversity of acute ischemic stroke, guide clinical treatment and help to predict prognosis.?doi: 10.3969/j.issn.1672-6731.2014.10.013.