Determination of Memantine Hydrochloride by Spectrophotometry using Anionic Dyes, Bromothymol Blue and Solochrome Black T, in Bulk and Tablet Dosage Forms

摘要

Three spectrophotometric methods are described for the determination of memantine hydrochloride (MTH) in bulk and tablet dosage forms. The methods are based on the formation of ion-pairs of the MTH with anionic dyes such as bromothymol blue (BTB) and solochrome black T (SBT), which are extracted into chloroform and have absorption maxima at 415 nm (BTB) and 510 nm (SBT). Regression analysis of the Beer's plots showed good correlation in the concentration ranges 2–20 and 5–25 μg/mL for BTB and SBT, respectively. The proposed methods were successfully applied to the tablet dosage forms containing the MTH. No interference from common excipients was observed.