Electrochemical fluoromethylation triggered lactonizations of alkenes under semi-aqueous conditions

摘要

An electrochemical difluoromethylation triggered lactonization of alkenes was developed for the first time. This protocol employs readily prepared CF _(2) HSO _(2) Na as the difluoromethylating reagent, affording unprecedented CF _(2) H-containing lactones in moderate yields. Moreover, with CF _(3) SO _(2) Na as the trifluoromethylating reagent, a wide array of CF _(3) -containing lactones were obtained under additional supporting electrolyte- and catalyst-free conditions.