Synthesis of New Pyrrolidine-1,2-dicarboxamidesand Investigation of Their Activity for the Synthesisof Aminonitriles

摘要

New pyrrolidine-1,2-dicarboxamide derivatives were synthesized by the amidation reactions of some amines, an amino alcohol and an amino acid ester with (S)-1-(phenylcarbamoyl)pyrrolidin-2-carboxylic acid, which was obtained from the reaction of L-proline with phenylisocyanate. Activities of these compounds for the synthesis of aminonitriles have been investigated. The organocatalysts catalyzed the reaction with good yields, while they did not showed any significant asymmetric induction.