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New process for the synthesis of (7-methoxy-1-naphthyl)acetonitrile and application in the synthesisof agomelatine
New process for the synthesis of (7-methoxy-1-naphthyl)acetonitrile and application in the synthesisof agomelatine
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机译:合成(7-甲氧基-1-萘基)乙腈的新方法及其在阿戈美拉汀的合成中的应用
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摘要
Process for industrial synthesizing of (7-methoxy-naphthalen-1-yl)-acetonitrile (I) comprises: reacting 7-methoxy-1-naphthoic acid (III) with a reducing agent to give (7-methoxy-naphthalen-1-yl)-methanol compound (IV); and reacting (IV) of which the hydroxyl group is transformed, with a cyanation reagent to obtain (I), which is isolated in solid form. An independent claim is included for a process of synthesizing agomelatin from (I), comprising subjecting (I) for reduction followed by coupling with acetic anhydride.
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