Synthesis of 18F-difluoromethylarenes using aryl boronic acids, ethyl bromofluoroacetate and [18F]fluoride

摘要

Herein, we report the radiosynthesis of ~(18) F-difluoromethylarenes via the assembly of three components, a boron reagent, ethyl bromofluoroacetate, and cyclotron-produced non-carrier added [ ~(18) F]fluoride. The two key steps are a copper-catalysed cross-coupling reaction, and a Mn-mediated ~(18) F-fluorodecarboxylation.